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藏药标准化与新药研发

青海省青藏高原特色生物资源工程技术研究中心 副主任
中国材料与试验标准委员会/科学实验领域委员会科学试验装置标准化技术委员会/资源与环境检测分技术委员会 副秘书长

1. 2012年 中国科学院西北高原生物研究所 地奥奖学金二等奖
2. 2012年 中国科学院西北高原生物研究所 优秀毕业生
3. 中国科学院西北高原生物研究所2017年度 、2022年度先进工作者
4. 2023年 中国科学技术协会 科研仪器案例库二类优秀案例
5. 2023年 青海省科学成果奖 创新驱动奖牌（2/15）

代表性论文 ：
1.Tao Chen, Jing Jia, Cheng Shen, Shuo Wang, Hongmei Li, Yumei Ma, Zhibo Song, Weihang Lu, Aijing Li, Yulin Li*, UV-based solvent system screening for high-speed counter-current chromatography fractionation of compounds with similar UV absorption from complex samples followed by preparative HPLC purification: Flavonoids from barley seedlings as sample, Journal of Separation Science, 2023;2300558.
2.Tao Chen, Jing Jia, Denglang Zou, Cheng Shen, Shuo Wang, Xiuzhen Gao, Zhongxiang Yun, Jialin Ma, Jing Zhao, Huan Wang, Yulin Li, Nuclear magnetic resonance-based solvent system selection for counter-current chromatography separation of compounds present in the same high-performance liquid chromatography peak: Flavonoids in barley seedlings as an example, Journal of Separation Science, 2023;2300406.
3.Tao Chen, Qi Wang, Qiqi Wang, Mencuo La, Yulin Li*, Liangliang He*, Denglang Zou*, Ab initio calculation based solvent system selection in silico for counter-current chromatography: Separation of resibufogenin glycosylation products ，Journal of Chromatography A ，1686 (2022) 463649.
4.Tao Chen, Xue Yang, Shuo Wang, Cheng Shen, Hongmei Li, Yangfei Wei, Shuping Yan, Zhibo Song, Fengmei Yang, Yarong Liu, Ping Hai*, Yulin Li*, Separation of five flavone glycosides including two groups with similar polarities from Dracocephalum tanguticum by combination of three high‐speed counter‐current chromatography modes, Journal of Separation Science, 2022, 45:468-476.
5.Tao Chen, Xue Yang, Nana Wang, Hongmei Li, Jingyang Zhao, Yulin Li*, Separation of six compounds including two n-butyrophenone isomers and two stibene isomers from Rheum tanguticum Maxim by recycling high speed counter-current chromatography and preparative high-performance liquid chromatography, Journal of Separation Science, 2018, 41:3660–3668.
6.Tao Chen, Ping Wang, Nana Wang, Chongyang Sun, Xue Yang, Hongmei Li, Guoying Zhou, Yulin Li*, Separation of three polar compounds from Rheum tanguticum by high-speed countercurrent chromatography with an ethyl acetate/glacial acetic acid/water system, Journal of Separation Science, 2018, 41:1775-1780.
7.Tao Chen, Hongmei Li, Denglang Zou, Yongling Liu, Chen Chen, Guoying Zhou, Yulin Li*, Separation of three anthraquinone glycosides including two isomers by preparative high-performance liquid chromatography and high-speed countercurrent chromatography from Rheum tanguticum Maxim. ex Balf, Journal of Separation Science, 2016, 39:3105-3112.
8.Tao Chen, Hongmei Li, Denglang Zou, Yuzhi Du, Yuhu Shen, Yulin Li*, Preparation of two flavonoid glycosides with unique structures from barley seedlings by membrane separation technology and preparative high-performance liquid chromatography, Journal of Separation Science, 2014, 37:3760-3766.
9.Tao Chen, Yongling Liu, Chen Chen, Denglang Zou, Jinmao You, Jing Sun, Yulin Li*, Application of High-speed Counter-current Chromatography Combined with Macroporous Resin for Rapid Enrichment and Separation of Three Anthraquinone Glycosides and One Stilbene Glycoside from Rheum tanguticum, Journal of Chromatography B, 2014, 957:90-95.
10.Tao Chen, Yongling Liu, Denglang Zou, Chen Chen, Jinmao You, Guoying Zhou, Jing Sun, Yulin Li*, Application of an efficient strategy based on liquid-liquid extraction, high-speed counter-current chromatography and preparative HPLC for rapid enrichment, separation and purification of four anthraquinones from Rheum tanguticum, Journal of Separation Science, 2014, 37:165-170.
科技成果 ：
1.甘青青兰和抱茎獐牙菜化学成分高效分离制备及标准化研究 ，9632023Y0131
2.唐古特大黄活性成分高效分离制备技术研究 ，9632021Y0534
3.高速逆流色谱仪功能开发及其在藏药天然产物分离中的应用 ，9632021Y0467
授权专利 ：
1.黑果枸杞花青素提取物和冻干粉的制备方法及其在抗痛风性关节炎和降尿酸保健产品中的应用, ZL202111272267.2
2.一种铁棒锤药材中8种酚类化学对照品的制备方法, ZL202110622651.4
3.一种甘青青兰药材中三种化学对照品的制备新方法, ZL201711081437.2
4.一种大黄药材中二苯乙烯类和苯丁酮类化学对照品的制备新方法, ZL201710568073.4
5.大黄中蒽醌苷类物质的分离方法, ZL201610450866.1
6.大黄药材中蒽醌苷和二苯乙烯苷化学对照品的制备方法, ZL201310308054.X
7.青海柴达木枸杞多糖提取分离制备新方法, ZL201410327027.1
国家标准样品 ：
1.国家天然产物标准样品“胡麻苷”（GSB11-3722-2020）
2.国家天然产物标准样品“雏菊叶龙胆酮”（GSB11-3720-2020）

1. 国家标准样品研复制计划项目 ：山栀苷甲酯纯度标准样品 ，2023.01-2024.12 ，主持
2. 青海省应用基础研究项目 ：青稞幼苗中降血压活性成分高通量筛选及活性评价研究 ，2022.01-2024.12 ，主持
3. 西宁市引才聚才555计划（培养第三类人才）项目 ，2022.01-2024.12 ，主持
4. 中国科学院青年创新促进会人才培养项目 ，2020.01-2023.12 ，主持
5. 中国科学院-青海省三江源国家公园联合专项子课题 ：唐古特大黄地上部分降血糖化学成分研究 ，2020.08-2022.07 ，主持
6.中国科学院兰州资源环境科学大型仪器区域中心自主知识课题 ：藏药材甘青青兰和抱茎獐牙菜中对照品的制备技术开发 ，2019.04-2021.04 ，主持
7. 中国科学院仪器功能开发项目 ：循环通用型高速逆流色谱仪改造 ，2015.07-2017.07 ，主持